“Assessing risk of bias in systematic reviews: why, how and new developments” By Miranda Langendam
Date: Thursday September 12th 2019
Time: 15.00-17.00 pm
Location: HvA Building A2.06.1/06.2 (Nicolaes Tulphuis, nearby AMC)
The extent to which a systematic review can draw conclusions depends on whether the results from the included studies are valid. A meta-analysis of invalid studies may produce a misleading result, for example a wrong intervention effect estimate. Assessment of risk of bias in the included studies is therefore an essential step in performing a systematic review, and the results should influence the analysis, interpretation and conclusions of the review. In this interactive tutorial we will start with the basics by discussing the general principles, including how to present the risk of bias assessment and how to incorporate the assessment in the analysis, and by providing a general overview of how these general principles work out for different types of review questions (e.g. intervention, diagnosis, prognosis, preclinical). In the second part of the tutorial we will take a more in-depth look at new developments in considering bias in systematic reviews of interventions: the new version of the Cochrane risk of bias tool for randomized studies (RoB 2) and ROBINS-I tool for non-randomized studies of interventions.