Program leaders:            Huibert Mansvelder, Helmut Kessels
Taskforce team:              Johannes de Boer, Rick Schuurman
Program members

Rationale and common goals

To understand how networks of neurons and brain areas give rise to brain function and behavior is a major goal of Neuroscience. In addition, studying the interaction of the central nervous system with peripheral organs offers new avenues to improve health. The research program of Systems & Network Neuroscience brings together research groups using invasive and non-invasive approaches in the living brain to study and manipulate brain networks in health and disease.

This program promotes the implementation of technological advances in neuroscience such as: MEG, EEG, deep brain stimulation (DBS), TMS/TDCS, resective brain surgery, in vivo nerve stimulation, in vivo neuronal and network recordings, opto-and chemogenetic manipulations, Optical Coherence Tomography (OCT) of the human retina, miniscope and 2P imaging, functional magnetic resonance imaging (fMRI), PET scans, computational approaches and others.

A major focus of the program is on understanding brain networks for sensory processing, motor control, cognition, mood, reward and harnessing collaborations on cross-discipline functional studies of brain function in relation to health.

Assets

  • Excellent research groups with top publications
  • Strong complimentary expertise at both Universities and Amsterdam UMC on neurotechnology
  • Strong ties with clinical departments with large patient cohorts for current and future application of technologies
  • Strong links with Industry to facilitate technological developments

Profiling

  • Study of network function and pathophysiological mechanisms of disease at the systems level
  • A mechanistic understanding of how networks of neurons give rise to brain function and behavior
  • Use of cell-type and network specific manipulations of brain function in health and disease
  • Examine how neural activity in the central nervous system coordinates the activity between the brain and body
  • Design and engineering of electrophysiologicalor mechanical systems that control sensory feedback and information processing in the brain
  • Improvement of clinical applications of technologies developed within and outside Neuroscience Amsterdam

Making the difference?

This research program relates to the fundamental as well as the clinical themes in Amsterdam Neuroscience, with good connections to industry, facilitating novel technological developments. Applying these technologies to study and manipulate neuronal and brain networks in the living brain and actively apply it to the treatment of pathological conditions will not only increase understanding of how brain networks give rise to function, but will also have direct impact on health prospects of patients.