PhD Candidate on Resistance Mechanisms in Esophageal Cancer - AMC

Reageer voor:6 oktober 2017 / Soort dienstverband:Bepaalde tijd / Aantal uren:36 uur per week / Vakgebied:AMC Medical Research (AMR)

The job

We are offering a position at the Laboratory for Experimental Oncology (LEXOR) in collaboration with the Department of Medical Oncology at the Academic Medical Center Amsterdam. Recent work from our group has established that therapeutic pressure results in epithelial-to-mesenchymal transition (EMT) in esophageal cancer, and that this drives resistance to therapy. Given that therapy resistance is an enormous hurdle to the effective treatment of esophageal cancer, this project offers an opportunity to improve outcome of this devastating malignancy.   The PhD candidate will elucidate the mechanisms that drive this resistance and develop markers that predict its occurrence in patients. Our group has established a unique set of patient-derived models and archived material that will allow cutting-edge experimental work. This will include in vitro and in vivo tumor experiments, bioinformatics, and the analysis of patient material including blood and tissue samples and clinical data.

Our department

The Laboratory for Experimental Oncology (LEXOR) is part of the Academic Medical Center Amsterdam (AMC). The AMC has a very strong track record in gastrointestinal research and offers a unique environment for ambitious PhD candidates to perform research in.

LEXOR is a vibrant laboratory that hosts approximately 30 PhD students and post-docs with diverse backgrounds (biomedical, physics, bioinformatics). Research focuses on cancers of the digestive tract (i.e. colorectal, pancreatic and esophageal) and has yielded numerous high-impact papers in recent years.

PhD candidates at the AMC are embedded in the Oncology Graduate School Amsterdam (OOA) and are offered a custom training- and guidance plan that aids in education, research, writing, and personal development.

Your experience

For this position, the candidate should hold a Master’s degree in biology, medical biology, medicine, or a related field. The candidate is preferably experienced in cell culture, bioinformatics, mouse experiments, and preferably communication with patients. A keen interest in cell biology and next-generation sequencing is preferred, as is a can-do mentality, ambition, and team player spirit.

Our offer

You will be offered an employment contract for a period of 1 year at the AMC. You will be employed by AMC Medical Research BV.

The salary is in accordance with the UMC-CAO. PhD students (Onderzoeker in Opleiding) are placed in scale 21, with a fulltime gross salary that ranges from €2.266,- to €2.903,- and is based on qualifications and experience. For a doctor (Arts-Onderzoeker) it’s scale 10, with a fulltime gross salary that ranges from €2.903,- to €4.194,- and is based on qualifications and experience.

In addition we offer a vacation allowance of 8% of the gross yearly salary and an end-of-year bonus of 8.3%.

Your application

For further information about the position, please contact Maarten Bijlsma (principal investigator), e-mail: or telephone: +31(0)20-5664824, or Hanneke van Laarhoven (professor of oncology), e-mail: or telephone: +31(0)20-5665955.

Acquisition related to this vacancy is not appreciated.

Vragen over deze functie?

Neem contact op met Bijlsma, M. (Maarten)


Over AMC Medical Research

De AMR heeft 1.600 extern en 400 intern gefinancierde projecten in beheer. De externe subsidiegevers zijn industriepartijen, collectebusfondsen, semi-overheidsinstellingen (ZonMW, NWO) en de Europese Commissie. Deze projecten zijn onderverdeeld in de portefeuilles van 11 projectcontrollers die aangestuurd worden door het Hoofd Projectcontrol.