Amsterdam Preclinical Imaging Laboratories

High-resolution in vivo MRI of a mouse heart High-resolution in vivo MRI of a mouse heart

The use of small-animal imaging provides unique opportunities for studying disease in real time, in a quantitative way, at the molecular level, along with the ability to longitudinally monitor disease progression or response to therapy. The combination of several imaging techniques, so-called multi-modality imaging, will continue to broaden the applications in such key areas as cardiovascular diseases (e.g. atherosclerosis, myocardial infarction), cancer, neurology (e.g. neurodegenerative diseases), and drug development.

The Amsterdam Preclinical Imaging Laboratories (APRIL) is a core-facility of the AMC/VUmc alliance. Its mission is to advance the development and use of non-invasive multi-modality imaging technology by research and teaching and to provide support to 3rd party users who want to integrate preclinical imaging in their translational research.

3D-FICS of mouse liver vasculature with metastasis (blue) 3D-FICS of mouse liver vasculature with metastasis (blue)

The facility is equipped with state-of-the art equipment for mouse and rat imaging, including Magnetic Resonance Imaging (7T-MRI), Single Photon Emission Tomography (SPECT), Positron Emission Tomography (PET/CT and PET/MRI), Ultrasound, a 3D Fluorescence Imaging Cryomicrotome System (3D-FICS), various optical imaging technologies, and other emerging technologies such as optical coherence tomography (OCT).

For additional information and inquiries on how to integrate preclinical imaging in your research, please contact prof. Gustav Strijkers (g.j.strijkers@amc.uva.nl).