The mission of the Amsterdam Cardiovascular Sciences is to design knowledge-based treatment strategies to prevent and cure cardiovascular disease. For this purpose, education, research and clinical activities are concentrated in four Centers of Excellence that not only translate experiments to clinical interventions, but also use clinical observations to develop and validate novel biological concepts. In this framework, we interconnect excellence in clinical and basic research and provide a unique infrastructure to train and attract talented cardiovascular researchers. Having successfully achieved this a number of times, we further expect that our translational research approach will lead to discovery and proof of concept of innovative, effective strategies, which improve cardiovascular health.