Awarded ACS grants 2017-2019

2019

Bianca Brundel/Riekelt Houtkooper (OOTB-2)
Staging of clinical atrial fibrillation: metabolomics as diagnostic tool?

Elga de Vries/Carlie de Vries (OOTB-2)
Four and a half lim domain 2 (fhl2) regulates vascular barrier function in aorta and brain microvasculature

Ed Eringa/Jeffrey Kroon (OOTB-2)
Get to the heart of the matter: mapping metabolic reprogramming in valvular interstitial cells in order
to combat aortic valve stenosis

Peter Hordijk/Ed van Bavel (OOTB-2)
Endothelial-cardiomyocyte communication through electrical coupling

Arjan Houweling/Vivian de Waard (OOTB-2)
Unravelling modifier genes responsible for variable clinical presentation of aortic complications in marfan syndrome

Mathilde Rivaud/Veronique Meijborg/Paul Wijnker (OOTB-2)
Effects of modifying electrical diastole on diastolic function

Eliane Wenstedt/Liffert Vogt/Niels Heemskerk/Jan van den Bossche (OOTB-2)
Does salt consumption drive leukocyte infiltration in humans

Pranav Bhagirath (MD/PhD)
Defining atrial cardiomyopathy using serial evaluation with cardiac magnetic resonance imaging and biomarkers in patients with atrial fibrillation (DESCRIBE-AF trial)

Jouke Bokma (MD/PhD)
To optimize timing of pulmonary valve replacement in adults with tetralogy of Fallot

Camiel de Roij van Zuijdewijn (MD/PhD)
Peri- and intradialytic hemodynamic stability in patients treated with various dialysis modalities

Fleur Tjong  (MD/PhD)
Deep learning models for development of novel tools for identification of patients at risk of complications and shock therapy following pacemaker and ICD implantation

Daniël van Raalte/Carlie de Vries (OOTB)
LIM-domain only protein FHL2 secreted? An unexpected finding requiring further research.

Jurjan Aman/Stephan Huveneers (OOTB)
Linking early endothelial barrier injury to vascular remodelling: a role for SOX17 in the onset of pulmonary hypertension.

Vivian de Waard/Dimitra Micha (OOTB)
The two genetic Marfan subtypes deserve a mouse model for preclinical studies.

Esther Creemers/Bianca Brundel (OOTB)
Uncovering atrial cardiomyocyte proteostais derailment and atrial fibrillation

Roddy Walsh (Postdoc)
Identifying genetic factors that influence variable penetrance and disease expressivity in hypertrophic cardiomyopathy

Natalija Bogunovic (Postdoc)
PRDM protein family as novel transcriptional regulators of aortic aneurysm pathology

2018

Reinier Boon/Stephan Huveneers (OIO)
Towards Protective Building Blocks for the Endothelial Barrier

Max Nieuwdorp/Majon Muller/ Han Levels/Mike Peters (OIO)
The gut microbiome and aging of the vascular system

Menno de Winther/Jan van de Bossche/ Michel van Weeghel (OIO)
Local immunometabolites shape inflammatory macrophages and atherosclerosis progression

Ed Eringa/Gustav Strijkers/Carlie de Vries (ACS-VUmc Equipment grant)
Contrast ultrasonography for identifying and understanding perfusion defects in organ failure

Marco Götte/Alexander Vonk (ACS-VUmc Equipment grant)
Mri-Compatible Multi-Channel Hemodynamic Monitoring System, Philips In Vivo MR Expression 400

Coert Zuurbier/Jolanda van der Velden (OOTB)
Targeting genetic heart disease with diabetes medication

Carol Ann Remme/Diederik Kuster (OOTB)
Keeping cardiomyocytes dynamic and exciting: a novel approach to prevent mechanical and electrical dysfunction in cardiomyopathy

Noam Zelcer/Elga de Vries (OOTB)
The nuclear receptors Liver X Receptors (LXRS) couple lipid metabolism to control of vascular integrity of the blood-brain barrier

Louis Handoko/Ot Bakermans (OOTB)
TrimetaziDine as a Performance-enhancING drug in heart failure with preserved ejection fraction (DoPING-HFpEF)

Leo Heunks/Coen Ottenheijm/Janneke Horn (OOTB)
Positive end expiratory pressure (PEEP) applied during mechanical ventilation as a novel mechanism to explain critical illness associated diaphragm weakness

Yu-Sok Kim/Johannes van Lieshout (OOTB)
Effect of treatment modality on cerebrovascular control and cognitive function in patients with end-stage renal disease - hemodiafiltration vs. hemodialysis

Peter van Tintelen/Bianca Brundel (OOTB)
A giant molecule underlying a major disease?

Ibrahim Danad (MD/PhD)
CT perfusion Imaging for the assessment of functionally relevant CAD as Indexed by 15O[H2O] PET and Fractional Flow Reserve

Rik Olde Engberink (MD/PhD)
The endothelial surface layer as orchestrator of interstitial Na+ homeostasis

Ralf Harskamp (MD/PhD)
Triage in acute chest pain evaluation in primary care (TRACE)

Thijs van Mens (MD/PhD)
Defining the role of gut microbiome pathways in venous thromboembolism pathophysiology

Debbie Kalkman (Postdoc)
Prevention of in-stent restenosis in diabetic patients with coronary artery disease

Marit Wiersma (Postdoc)
LMNA and DES mutations: undissolved role for cardiomyocyte proteostasis and AF promotion in familial atrial fibrillation

Paul Wijnker (Postdoc)
A disturbed redox-balance triggers cardiac disease in inherited cardiomyopathy

René Musters (ACS-VUmc Equipment grant)
Extension of  AO/2M Nikon A1-DUS MULTISPECTRALE-DETECTOR, improvement of platform functionality

Diederik Kuster/Charissa van den Brom (ACS-VUmc Equipment grant)
Fluorescent Western blot imager
Contact person: Diederik Kuster

Yu-Sok Kim/Frans van Ittersum (ACS-VUmc Equipment grant)
Trans Cranial Doppler
Contact person: Yu-Sok Kim

Yu-Sok Kim/Frans van Ittersum (ACS-VUmc Equipment grant)
Servo-controlled finger plethysmograph (Nexfin® or ClearSight EV1000®)
Contact person: Yu-Sok Kim

2017

Peter Hordijk/Stephan Huveneers (OIO)        
The Push and Pull of (dys)balanced endothelial integrity  

Reinier Boon/Riekelt Houtkooper (OIO)            
The role of long non-coding RNAs in regulating cardiac metabolism during aging         

Carlie de Vries/Ed Eringa/Daniel van Raalte/Max Nieuwdorp (OIO)              
Prevention of aging-related type 2 diabetes and vascular disease through LIM-domain only protein FHL2  

René Musters (ACS-VUmc Equipment grant)
Extension of the Leica TCS SP8 STED 3X platform with a OKO-labs microscopy environment, with climate control and live-cell
stage incubator together with a Navigator-stage-module extension of software possibilities

Peter Hordijk/Carlie de Vries (ACS-VUmc Equipment grant)
96 well ECIS machine and Reader (extension)   

Harm Jan Bogaard/Robert Szulcek (ACS-VUmc Equipment grant)
GentleMACS tissue dissociator with MultiMACS 24 cell separator