Hein van Marle receives NARSAD Young Investigator Grant to treat trauma during sleep

Hein van Marle, Amsterdam UMC (location VUmc) and GGZ inGeest, received $70.000 from the Brain & Behavior Research Foundation to further support his recently started TMR-TRAUMA study. With this study van Marle aims to open up sleep as a potential treatment window in post-traumatic stress disorder (PTSD). Recent advances show that memory consolidation can be significantly enhanced by presenting reminder cues during subsequent sleep (known as targeted memory reactivation). The study seeks to apply memory reactivation strategies during sleep in patients for the first time in an effort to increase therapy effectiveness. Van Marle will specifically test whether re-administering auditory cues that are already part of a treatment, again, during subsequent sleep, will strengthen the (re)consolidation of updated traumatic memory. To visualize the underlying reorganization of the traumatic memory in the brain, he will additionally obtain functional MRI during scripted recall of the traumatic event pre/post study. The US-based Brain & Behavior Research Foundation annually awards 200 grants worldwide to early-career scientists, who pursue innovative mental health research. As 1 of 2 Dutch recipients, van Marle was awarded in the category Next-Generation Therapies.