Speaker: Gerald I. Shulman, Howard Hughes Medical Institute and Yale Diabetes Research Center, Yale University School of Medicine, New Haven, USA
Title: Ectopic Lipid-Induced Insulin Resistance: Implications for Obesity, Type 2 Diabetes and Lipodystrophy
Abstract: Nonalcoholic fatty liver disease (NAFLD) is a major factor in the pathogenesis of type 2 diabetes (T2D) and nonalcoholic steatohepatitis (NASH). Professor Shulman will focus on the cellular mechanisms of liver and muscle insulin resistance in humans and the role of dysregulated intracellular lipid metabolism in its pathogenesis. Recent studies have implicated diacylglycerol, as the molecular trigger for lipid-induced insulin resistance through its activation of PKC-epsilon in liver and PKC-theta in skeletal muscle leading to inhibition of insulin signaling. Also, a link was identified between white adipose tissue inflammation and increased rates of hepatic gluconeogenesis and fasting hyperglycemia in patients with T2D due to increased rates of lipolysis leading to increased hepatic acetyl CoA content and allosteric activation of pyruvate carboxylase.
Hosts: Mireille Serlie and Kasper ter Horst, Internal Medicine – Endocrinology and Metabolism